https://www.drugnerd.net/blog daily 1.0 2024-05-28 https://www.drugnerd.net/blog/what-determines-a-drugs-speed-of-onset-4hg7f monthly 0.5 2023-11-16 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/70b05f36-e54c-461c-a9ed-b0eae597db6c/food.png Blog - What determines a drug's speed of onset? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/efd25db7-b091-48fa-8558-f730ea3cf617/pills_on_scale.png Blog - What determines a drug's speed of onset? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/0c35ffa4-6395-4549-90f2-1ada9a81bb80/RoA.png Blog - What determines a drug's speed of onset? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.drugnerd.net/blog/pharmacodynamics-basics-what-the-hell-is-an-agonist-or-antagonist-25gz7 monthly 0.5 2023-07-17 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/34b57b92-8c1a-4200-bc47-678904abbc77/Efficacy_spectrum.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/722b74d3-4e5f-48fc-91f0-f22168378366/synapse.JPG Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? A Synapse https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2e47fc6b-a4b8-463d-925c-f2be9be4b810/neuron.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - Make it stand out A Neuron https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9cfcd80e-69d9-459f-b5ea-af49742558e8/receptor.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - Make it stand out Ligands Binding to Receptors https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/81984bae-afc0-4041-bbd1-b3e7340bdda5/agonists.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/13d4c6bc-5f55-43a5-8eb9-8322af17a9b7/lsd.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - LSD LSD https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/37833a11-663d-4b2f-b0ad-201341501a0e/dmt.png Blog - Pharmacodynamics Basics. What the hell is an agonist or antagonist? - DMT DMT https://www.drugnerd.net/blog/serotonin-is-it-really-the-happiness-chemical-abjlb monthly 0.5 2023-07-17 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/450d15d6-bcec-4af7-802f-9092d5867b68/euphoria.png Blog - Serotonin, is it Really the Happiness Chemical? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e7b65776-124c-4942-b6ca-ae25c2803496/Serotonin.png Blog - Serotonin, is it Really the Happiness Chemical? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/721a4ec2-86b9-48c2-af7a-87db3966fbf6/ginger.png Blog - Serotonin, is it Really the Happiness Chemical? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/84497a1a-ab47-411b-a148-30add5665bd7/comedy_tragedy.png Blog - Serotonin, is it Really the Happiness Chemical? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e64d6159-eed2-4b7c-8769-9d4d3ef49e36/locusts.png Blog - Serotonin, is it Really the Happiness Chemical? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.drugnerd.net/blog/ok-dopamine-must-be-the-happiness-molecule-then-right-lc5ml monthly 0.5 2023-07-17 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/23a00724-1600-4be8-9510-3d6407931fde/mesolimbic.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/aa765098-ca13-4598-acca-af9d8a747335/nacc.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/64befa5c-50bf-4ada-9d34-2f821b90316d/reward_2.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Rewarding Stimuli are Often Also Pleasurable https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/a19bee1b-d22d-47f6-b1e6-b3a82a3a9290/couple.jpg Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/114b6cf0-105c-49e3-95ce-40c7ed32eccf/pfc.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2927b4bc-54f1-4648-8e0c-e943a401b448/pleasure.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e19e12b8-65c9-49e9-9885-ba9e83b0e168/striatum.png Blog - Ok, Dopamine MUST be the Happiness Molecule Then... Right? - Make it stand out Striatum in Red https://www.drugnerd.net/blog/the-major-drug-classes-and-their-subjective-effects-3m3mm-qV17p monthly 0.5 2023-08-11 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/19fce399-8e7f-4a95-b8da-b1f2df35c325/coke.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out A well known recreational stimulant... And some cocaine next to it https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/b4bf4d3f-5e3b-4a4e-8385-fcfd1770b641/mdma3.jpg Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/7d61af47-36e6-4f76-bc46-155b8d755ea1/shrooms.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/27c65322-16ff-4d92-90af-000c287b10ef/alcohol.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e722dd7f-1c67-41c1-8ac5-82e576a03039/marijuana.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/a913d3c7-a10a-4eca-a11d-42a7429a41dc/datura.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Datura Flower - The seeds of this plant contain Atropine, Scopolamine, and Hyoscyamine. Perhaps one of the most well known natural Deliriants, and a notorious historical poison. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/63a02c03-58fe-4e45-b62c-d09fc7196cb1/opiumpoppy.png Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/815f9c4d-8a39-410c-801c-e99fe7052524/whippets.jpg Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/70444167-48cb-4993-84f6-02b2e4693559/spy.jpeg Blog - The Major Drug Classes and Their Subjective Effects - Make it stand out Phenibut will give you the "social confidence of James Bond" according to many of its users https://www.drugnerd.net/blog/the-various-drugs-that-affect-the monthly 0.5 2023-07-17 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/03adcb9e-0ea6-4447-b7ea-0f4e8adbe687/sergio-alves-santos-OxKFC5u0980-unsplash.jpeg Blog - Various Drugs that Affect the GABA A Receptor - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9fb7d5a3-90be-4f41-b4d7-f3210cd391e4/gaba.png Blog - Various Drugs that Affect the GABA A Receptor - Make it stand out Gamma Amino Butyric Acid https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/0939f847-bb40-4cc5-a1ea-5e2b946f49fa/flumazenil.jpeg Blog - Various Drugs that Affect the GABA A Receptor - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f0aff6c3-e74f-4342-9639-a37548538c79/ambienwalrus.gif Blog - Various Drugs that Affect the GABA A Receptor - Make it stand out From the webcomic “Toothpaste for Dinner”: https://www.toothpastefordinner.com/index.php?search=Ambien+Walrus https://www.drugnerd.net/blog/how-does-nausea-work-and-how-do-we-stop-it monthly 0.5 2024-02-28 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/1b26dac3-5371-404f-bb18-f32bb7c66b08/ondansetron.png Blog - How Does Nausea Work and How Do We Stop It? - Make it stand out Ondansetron aka Zofran https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2e7d4108-c35f-4acb-b97a-0e9f8d878363/Gingerol.png Blog - How Does Nausea Work and How Do We Stop It? - Make it stand out Gingerol, One of the Active Components of Ginger https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/0e498673-186e-4ed2-b65f-7ddbd45b79a9/Ionophore_receptor.jpeg Blog - How Does Nausea Work and How Do We Stop It? - Make it stand out 5ht3 Receptor Subunits https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2f9d9af5-47b7-46e5-a19f-5e982e9575e9/emetic+ligands.jpeg Blog - How Does Nausea Work and How Do We Stop It? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/56561726-7018-4f21-9ea0-70dc53980f40/nausea.jpeg Blog - How Does Nausea Work and How Do We Stop It? - Make it stand out Nausea sucks https://www.drugnerd.net/blog/whats-the-deal-with-synthetic-cannabinoids-are-they-all-dangerous monthly 0.5 2024-02-28 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/8f838eba-37e3-40d3-a4af-75f8a43cea02/Delta-8-THC_Structure.svg.png Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out Delta 8-THC, a Federally Legal (in the US) Minor Alt-Cannabinoid of Recent Popularity https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9e20daa3-01c3-4922-bbcc-39fc9f797e2f/ydoe.png Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/1232c998-fbc7-44d8-84b1-e926fa6d4e1a/snoop.jpg Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out “Smoke weed everyday” [attribution] https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/a30a54f6-2eb2-4b12-85dd-eeda67eee84d/marijuana_lots.png Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/6ce817d6-1eb8-4b7f-ba31-8aa04f4daacc/synthetics.gif Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out A Selection of Synthetic Cannabinoids [attribution] https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/7178ae40-c012-4827-b77c-c5123d1b420a/thc.png Blog - What’s the Deal with Synthetic Cannabinoids… Are They All Dangerous? - Make it stand out Delta 9-THC aka “Normal” THC https://www.drugnerd.net/blog/ea-3167-into-the-never-ending-abyss monthly 0.5 2023-11-12 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2e65b278-b038-406d-90b6-fd3558c52390/Shadow_People.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Omnious “shadow people”, a common deliriant hallucination https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/8d6a2b82-d818-4299-bc4e-7acda19347fd/US_WWI_Gas_mask_with_bag.JPG Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Sourced from Wikimedia: https://commons.wikimedia.org/wiki/File:US_WWI_Gas_mask_with_bag.JPG https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/79931023-24aa-40a3-86c3-1487c7ecab6a/Aberdeen_Proving_Ground_Plaque.JPG Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Aberdeen Proving Ground, site of the Edgewood Arsenal Sourced from Wikimedia: https://commons.wikimedia.org/wiki/File:Aberdeen_Proving_Ground_Plaque.JPG https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/0bafd584-e21d-4b90-a405-c34ef0da01ed/Deliriants.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Replication of Deliriant effects by anonymous 4chan user on the /del/ board https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/244e8eb4-cbef-471b-bfcb-7bf131f496aa/Shadow-people_zpsaa95af9a.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/7088d752-3694-4cf2-8439-0c72a8c44e43/Lovecraftsnightmare.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Lovecraft's Nightmare by Michael Whelan A replication of the effect of “unspeakable horrors” that deliriants are known for https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/ca7dc347-56f0-420f-8236-a99adf1a5ae4/datura2.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out Datura stramonium: A notorious poisonous plant known for its deliriant effects. Datura seeds contain the anticholinergic compounds: Atropine, Scopolamine, and Hyoscyamine https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f1a1499e-9cd0-4f2e-ad52-1f2ccd0d0ae4/ea3167.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out EA-3167 aka 1-Azabicyclo[2.2.2]octan-8-yl 2-cyclopentyl-2-hydroxy-2-phenylethanoate https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2503b016-a2f0-44c1-a24b-d7e37d71272e/psychosis.jpg Blog - EA-3167: Into the Never-ending Abyss - Make it stand out My Eyes at the Moment of the Apparitions by German artist August Natterer https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f653fa52-0001-45e6-b03c-7b55111a4c00/Shadowlady.png Blog - EA-3167: Into the Never-ending Abyss - Make it stand out A “Shadow person”: Both a common deliriant hallucination and what you’ll feel like after experiencing EA-3167 Sourced from psychonautwiki: https://psychonautwiki.org/wiki/File:Shadowlady.jpg https://www.drugnerd.net/blog/the-drugnerd-combo-an-exploration-into-mimicking-the-effects-of-drinking-alcohol monthly 0.5 2024-02-28 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f2a55af2-02d3-4113-a18a-07b60c28344d/Ethanol-3D-balls.png Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out Ethanol https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/cbed28f3-bbff-47de-8d5d-b07dfcaed8d5/alcohol.png Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e2fdc286-547d-407c-8039-4a563fef7593/2m2b.png Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out 2m2b https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/635978a3-2515-4bf2-b090-76d3cb13440b/agricultural.jpg Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out The First Agricultural Revolution. Some even posit that settling into cities was done out of a need of organized manpower to brew beer https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2509e698-691c-4dd0-81b9-1a0f3da25a0f/phenibut.png Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out Disinhibition of Mesolimbic Dopamine is frequently cited as the reason behind Phenibut’s own paradoxical stimulating / pro-motivation effects https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/8efb57c7-f74c-4c81-8a5e-215c7cda79dc/The_Alcohol_Flushing_Response.png Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out Asian Glow or Asian Flush is caused by a genetic variation (common in asians) that leads to inhibited levels of alcohol dehydrogenase. Various symptoms arise due to an accumulation of acetaldehyde. Severe forms of this phenomenon could be termed as an alcohol allergy. Attribution: https://en.wikipedia.org/wiki/Alcohol_flush_reaction#/media/File:The_Alcohol_Flushing_Response.png https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/21b9d70c-aa19-4b30-a454-7148a2765ba0/ketamine1-283692632.jpg Blog - The Drugnerd Combo: An Exploration Into Mimicking the Effects of Drinking Alcohol - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.drugnerd.net/blog/22839-glutamate-the-tastiest-neurotransmitter monthly 0.5 2024-02-28 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e1005f88-daae-4708-a930-80b129c8a3cd/steak.png Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out Mmm Glutamate… https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/c16e3d2a-f3ce-4d8c-b38a-1e0e983e8573/AMPA_receptor.png Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out https://commons.wikimedia.org/wiki/File:AMPA_receptor.png https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/2f26d123-2eea-4fb5-954e-49ba6a495784/neuron.png Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out A neuron https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/6db4ebc5-c180-4008-8176-2d5add8e0f65/1402_The_Tongue.jpeg Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out https://en.wikipedia.org/wiki/Taste_bud#/media/File:1402_The_Tongue.jpg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9a625e84-2f64-422e-bb50-c9f868fb4582/Activated_NMDAR.svg.png Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out https://en.wikipedia.org/wiki/NMDA_receptor#/media/File:Activated_NMDAR.svg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/c0d533c5-9251-4384-a7bd-0fad6ab3d1e1/Monosodium_glutamate_crystals.jpeg Blog - Glutamate: The Tastiest Neurotransmitter - Make it stand out MSG, a savory spice: https://en.wikipedia.org/wiki/Monosodium_glutamate#/media/File:Monosodium_glutamate_crystals.jpg https://www.drugnerd.net/blog/defining-a-drugs-strength-what-is-potency-what-is-intrinsic-activity monthly 0.5 2023-12-26 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9c889e04-de6d-43a4-9e58-04496d619000/dmt.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/c4c7688c-732b-4de4-8b25-beb4a53c2c12/DALL%C2%B7E+2023-12-26+08.46.12+-+Create+an+image+of+a+scientist+measuring+two+drugs+with+a+scale+in+a+laboratory+setting.+The+scientist+is+focused+and+precise%2C+using+a+digital+or+trad.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/de1bc92e-037b-4284-b0b3-66443119981a/dmtpipe.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out A DMT pipe https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/963ae534-716d-4fd6-b2de-eb4d025f5494/lsd.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/d1357c7c-526f-46d7-960f-bd588dbcdd7f/DALL%C2%B7E+2023-12-26+08.49.21+-+Create+a+whimsical+and+imaginative+image+of+two+vials%2C+one+labeled+%27Morphine%27+and+the+other+labeled+%27Buprenorphine%2C%27+playing+a+game+of+musical+chairs.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Morphine and Buprenorphine playing Musical Chairs In this Musical Chairs analogy, the compound with a higher binding affinity essentially has longer legs / can run faster and has an easier time outcompeting the other compound in finding a chair in time. Image generated by Dalle 3 (ChatGPT 4.0), that’s why the text on the pill bottles are messed up. Just pretend you don't notice it pls. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/8203ae07-dbd3-4c8b-8d1d-e1f0daa0c906/1920px-Buprenorphine.svg.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Buprenorphine https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/1b062c9e-2bfe-467a-b02d-88643936329f/Agonists_v2.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Relationship between binding affinity and % of receptors that the ligand would bind to for a given concentration Source: https://en.wikipedia.org/wiki/File:Agonists_v2.png https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/5e9f7870-eaf8-44ed-8377-b31bd29b9afe/Agonist_2.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Chart showing that a partial agonist “caps out” at a lower “ceiling effect” than a full agonist, regardless of dosage Source: https://commons.wikimedia.org/wiki/File:Agonist_2.png https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9526c3b6-8a53-4e15-9d91-bfb3dd13d9aa/DALL%C2%B7E+2023-12-26+08.36.31+-+Create+an+image+of+a+pharmacologist+or+chemist+comparing+the+strengths+of+two+compounds.+The+scene+shows+a+scientist+in+a+laboratory+setting%2C+examinin.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/b73cb40f-e07c-44e7-871e-f01f9eef3621/DALL%C2%B7E+2023-12-26+08.47.34+-+Create+an+image+of+a+scientific+chart+showing+a+ceiling+dose.+The+chart+features+a+graph+with+an+X-axis+representing+dosage+and+a+Y-axis+representing+.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/741eaef3-1aa8-4f9d-8e47-1b0203e033d2/receptor.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Ligands binding to receptors https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9356704e-3bde-4dd6-bc02-6d3d6ec4e85e/Efficacy_spectrum.png Blog - Defining a Drug’s Strength. What is Potency? What is Intrinsic Activity? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.drugnerd.net/blog/how-does-mdma-work-is-combining-mdma-and-ssris-actually-dangerous monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/e8106ab3-6485-42a6-b493-066d78dc268a/SERT.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out SERT Source: https://en.wikipedia.org/wiki/File:SLC6A4.png https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/0496cfc9-af26-4417-b55c-addd2d6c54e4/TAAR1_Dopamine.svg.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out A diagram of how a trace amine (such as phenethylamine or amphetamine) activates TAAR1. This is a bit similar to how MDMA does it (I couldn’t find a more relevant diagram) https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9b616440-9639-46c8-958f-9ccde32b896b/mdma3.jpg Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/7eabb0d3-7b75-4f2a-9fe7-e0ca0c8f6f27/synapse2.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/fe2e48f7-b7f1-45fa-94e0-ea081ab23d59/file-kFdJmODGlHMZvWFvc6dX1odQ.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Is it safe though? Nah https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/9e6eecac-e01e-4e79-98ce-fb9218cc21c1/Serotonin.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Serotonin https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/67a77161-78b0-4a9c-b091-0b15b93b8002/Serotonin-Spartan-HF-based-on-xtal-3D-balls-web.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Serotonin https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/6baf3dcd-ed67-49f1-919b-cce7ebb9041f/Fluoxetine.svg.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out Fluoxetine aka Prozac (A common SSRI) https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f5157fa5-4533-45d7-9b9e-c66ff874e0a2/MDMA2.png Blog - How Does MDMA work? Is Combining MDMA and SSRIs Actually Dangerous? - Make it stand out MDMA https://www.drugnerd.net/blog/journey-of-a-neuron-firing-an-action-potential monthly 0.5 2024-03-08 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/6d594667-295e-4d2e-8f94-0556c647ba2d/1221_Action_Potential.jpg Blog - What Does a Neuron Actually Do?! - Make it stand out A cell is typically in a slightly negatively charged polarized state. Depolarization occurs when positive ions enter the neuron and induce a positively charged state Hyperpolarization occurs when negatively charged ions enter the cell and induce an even more negatively charged state Source: https://en.wikipedia.org/wiki/Depolarization#/media/File:1221_Action_Potential.jpg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/1e161a46-341c-4f0d-b66d-6aab7d228de7/gaba.png Blog - What Does a Neuron Actually Do?! - Make it stand out Gamma Amino-Butyric Acid (GABA), the primary inhibitory neurotransmitter https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/ca7d4605-c345-49ef-8ae8-a58f7bac2ca9/L-glutamic-acid-skeletal.png Blog - What Does a Neuron Actually Do?! - Make it stand out Glutamate: The primary excitatory neurotransmitter. Also a signal for umami taste (this is not a coincidence! See the previous article on glutamate for more information) https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/55d8fb5b-6a92-46e7-b612-07e5c333ced9/neuron.png Blog - What Does a Neuron Actually Do?! - Make it stand out Axon is labeled in this diagram https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/8fc533a1-63de-4a6b-aa1e-401accb65d01/5ht2a.jpg Blog - What Does a Neuron Actually Do?! - Make it stand out Serotonin Receptor Subtype 2A (5ht2a Receptor), a GPCR that allows different ligands to activate it in a selective manner allowing for complex effects that go far beyond a simple excitatory or inhibitory signal. Specialized ligands selectively activating (biased agonism) the 5ht2a receptor is the primary mechanism behind psychedelic hallucinations. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/db287193-376d-4b06-92b1-8e5685592bad/1206_The_Neuron.jpg Blog - What Does a Neuron Actually Do?! - Make it stand out Diagram of a typical neuron. Pay extra attention to the Dendrites, Soma, and Axon of this neuron. We will be discussing them heavily in this article. This article will go section by section, moving from the dendrites to the soma all the way down to the axon. Source: https://en.wikipedia.org/wiki/Depolarization#/media/File:1206_The_Neuron.jpg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/88ada83e-21de-4f4b-bd22-262fb7f21d51/synapse.png Blog - What Does a Neuron Actually Do?! - Make it stand out The top shows an axon terminal of a presynaptic neuron, while the bottom shows a dendrite terminal from a post synaptic neuron. The tiny gap between them in the middle is the synapse https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/f69cd79b-ac46-4a70-b1e3-314883ceb8ca/Sodium-channel.svg.png Blog - What Does a Neuron Actually Do?! - Make it stand out A series of VGSCs located next to each other. Each of these will fire one after another, leading to signal propagation down the length of the cell. Source: https://en.wikipedia.org/wiki/Depolarization#/media/File:1221_Action_Potential.jpg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/51ce1b77-4e14-40e7-8497-4bddc2e6da01/Capture.PNG Blog - What Does a Neuron Actually Do?! - Make it stand out Source: https://en.wikipedia.org/wiki/File:SynapseSchematic_lines.svg https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/3365ee1a-ea2d-4346-ad9a-ec9aa88fe34e/synapse2.png Blog - What Does a Neuron Actually Do?! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.drugnerd.net/blog/short-the-safety-profile-of-nitrous-oxide monthly 0.5 2024-05-28 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/dc7e621a-7726-4593-99e7-e63b20f796a4/Cobalamin_skeletal.svg.png Blog - Short: The Safety Profile of Nitrous Oxide - Make it stand out Vitamin B12 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/d58e6f10-07e7-42a1-baef-c9db87a2c0fc/file-fL7hQtdcqXstqYAdxEujB48Z.png Blog - Short: The Safety Profile of Nitrous Oxide - Make it stand out Xenon Gas. Amongst users who have tried many dissociatives, many point to Nitrous Oxide as the most euphoric amongst them. For the very select few people in the world who had the opportunity to try Xenon, the general consensus tends to be that it is even more euphoric than Nitrous, by a significant amount. Unfortunately Xenon is in extremely rare supply and a single dose costs $300-$400 (And don’t forget that it is a short lasting gas, so that $400 bucks buys you a minute or two of fun). https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/42901218-8dfc-4af1-bdeb-158322dfedfb/file-5NKAalokMFMah4u93orNL5bL.png Blog - Short: The Safety Profile of Nitrous Oxide - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/6a75c11d-2b39-4f45-9503-bc1065bfb71c/NOS_Cracker_With_Balloon_And_Charger.jpg Blog - Short: The Safety Profile of Nitrous Oxide - Make it stand out Attribution: https://psychonautwiki.org/wiki/File:NOS_Cracker_With_Balloon_And_Charger.jpg Despite what’s shown in this picture, whipped cream dispensers are far more preferred over crackers for use with nitrous. The dispenser tank itself acts as a container that can help further warm up the gas before being ingested https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/1fd89997-3a34-4f06-8c7b-872aa05dc954/olneyslesions.jpg Blog - Short: The Safety Profile of Nitrous Oxide - Make it stand out Olney’s Lesions Attribution: https://commons.wikimedia.org/wiki/File:Fnana-07-00023-g002.jpg https://www.drugnerd.net/blog/category/Pharmacodynamics monthly 0.5 https://www.drugnerd.net/blog/category/Neuroscience monthly 0.5 https://www.drugnerd.net/blog/category/Drug+History monthly 0.5 https://www.drugnerd.net/blog/category/Chemical+Weapons monthly 0.5 https://www.drugnerd.net/blog/category/Pharmacokinetics monthly 0.5 https://www.drugnerd.net/blog/category/Organic+Chemistry monthly 0.5 https://www.drugnerd.net/blog/category/Recreational monthly 0.5 https://www.drugnerd.net/blog/category/Pharmaceuticals monthly 0.5 https://www.drugnerd.net/what-we-do daily 0.75 2023-07-14 https://www.drugnerd.net/projects daily 0.75 2023-07-14 https://images.squarespace-cdn.com/content/v1/624b3c6d69f8ea5ba4177856/1649097856648-KPHW6ZA2QUMH6D6WCRL2/20140302_trade+151_0677.jpg https://images.squarespace-cdn.com/content/v1/624b3c6d69f8ea5ba4177856/1649097856654-R9NLROIHO9VT8W7NIO99/Aro+Ha_0073.jpg https://images.squarespace-cdn.com/content/v1/624b3c6d69f8ea5ba4177856/1649097856659-T0RN0JF7IZCOVW1JPKXV/20140228_Trade+151_0067+%281%29.jpg https://www.drugnerd.net/contact daily 0.75 2023-11-12 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/397c5775-0591-47d2-91fd-9ab4bd6ff7ff/TDN.png https://www.drugnerd.net/about daily 0.75 2023-07-16 https://images.squarespace-cdn.com/content/v1/64b1beb639c2942d73a49116/c81b1c91-e9e3-40de-bfe1-83090020b352/TDN.png